In 2022, more than 1 billion people worldwide were considered obese, broken down as follows — 650 million adults, 340 million adolescents and 39 million children. Image Credit: Gulf News file photo | Data source: WHO


  • Obesity is now one of the largest contributors to poor health worldwide.
  • Multiple studies show obesity is a key risk factor for heart disease.

The world is getting fatter, a new study shows. And with that comes all sorts of health issues, including heart disease, which causes 1 out of every 4 deaths in many countries.

Disturbingly, a new study published earlier this month in the Journal of the American Heart Association, an open access scientific publication, shows a three-fold increase in obesity-related deaths from heart disease in the US between 1999 and 2020.

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Experts underscore a key issue, i.e. recognising risk factors for heart disease: smoking, including cigarettes, pipes, vape and sheesha, which ranks among the most significant contributors to heart disease.

Other critical risk factors encompass obesity, diabetes, high blood pressure, high cholesterol, family history. Addressing these factors is imperative in curbing the menace.

heart disease key risk factors
Image Credit: Gulf News | Jay Hilotin

In 2022, Obesidemic: Weight of the World, a fascinating documentary that looks at obesity, was released on IMDb. In the 80-minute film, Stockholm-based obesity specialist Dr. Stephan Rossner sought to prove that obesity is a “man-made epidemic”. For one, it’s dubbed as a health “timebomb”.

Consider this: In 2022, more than 1 billion people worldwide were considered obese, broken down as follows — 650 million adults, 340 million adolescents and 39 million children.

World is getting fatter
Image Credit: Gulf News | Vijith Pukillak | Source: WHO

World Health Organisation (WHO) data shows being overweight is seen behind 2.8 million deaths each year; a number set to rise.

Obesity is seen overtaking smoking as the leading risk factor for avoidable cancer in several nations. It is known to have negative impacts on blood pressure, cholesterol, triglycerides, insulin resistance, and general quality of life.

Factors behind the emergence of “obesogenic”

The risks of obesity are well established, but the causes are not as well understood. Obesity risk is generally ascribed to two factors: environmental and genetic. A new third factor is emerging: neuro-developmental. Let's break them down.

1. Environmental factors

It’s down to lifestyle. Specifically, present-day eating habits. One question to ask is this: Why were there so few obese people up until the 1960s and 1970s?

In the last few decades, the rise of industrial agriculture producing raw food ingredients at very low cost per calorie output, has no doubt resolved global hunger. One unintended outcome: an overabundance of food. As globalisation advances, ingredients can be sourced from anywhere where production costs are lowest or heavily subsidised.

One question to ask is this
Why were there so few obese people up until the 1970s?

Moreover, urbanisation, labour-saving tech, app-driven take-aways of “super-sized” portions, alongside a multi-billion ad industry working with food companies that produce highly palatable and durable foods — smothered in sugar, salt and fat — together work for a waistline-busting affair.

Hypermarkets, too, have mushroomed with an abundance of processed foods, lower prices through their bulk purchasing power — aided by data-driven promos.

On a personal level, people have less time for sourcing, preparing and eating food. One study published in the Nutrition Journal shows that since 1965, US adults have consumed fewer foods produced at home and spend less time cooking.

Between 1965-1966 and 2007-2008, the percentage of daily energy taken from domestic food sources and time spent in food preparation declined dramatically for all socioeconomic levels, with the greatest decreases occurring between 1965 and 1992.

How to change the food environment? One solution proposed is via legislation — similar to tobacco controls and sugar tax in increasing number of jurisdiction, specifically geared towards salty and fatty processed foods.


In response, the food industry has unleashed “ready-to-heat” meals, “ready-to-eat” snack foods and “fast-food” outlets.

Dealing with the bulge is made more difficult in this type of climate — it's like attempting to drive personal responsibility, including in children, in an environment meant to undermine it.

Sugar types
Image Credit: Twitter | @WHO_Europe

For example, many child-oriented food products – notably yoghurt, drinks, breakfast cereals and dried fruit snacks – bear statements such as “no added sugar”. They come with bright and colourful packaging marked with cartoon designs to catch the eye of children, with claims about health benefits such as the presence of calcium or the addition of vitamins and nutrients.

While the “no added sugar” claim is technically true, these claims are misleading, the Daily Telegraph stated in a August 2022 report.

Obesogenic food supply
Numerous studies show the commercial food supply is itself “obesogenic”. In 2021, the US National Institutes of Health (NIH) reviewed multiple studies on food advertisements targetting children.

It concluded: “The most frequently reported sphere of action targeting children and adolescents was marketing and preference shaping.”

The NIH study has identified “commercial determinants of dietary behaviour associated with obesity… as being part of a complex system where corporate practices are enabled by power structures.”

It suggests a careful and systematic study — specifically on the “impact of specific aspects of food industry's strategies and increase primary prevention by anticipating industry responses and by discouraging corporate practices that harm health.”

How to change the food environment? One solution proposed is via legislation — similar to tobacco controls and sugar tax in increasing number of jurisdictions — specifically geared towards salty and fatty processed foods.

2. Genetic factors

Genes do not work in isolation from the environment, but they do have a role in obesity risk factors. According to a Harvard research, most people "certainly have some genetic propensity" to obesity, depending on family history and ethnicity.

The gene MC4R, which encodes the melanocortin 4 receptor, is the most frequently implicated. Changes in MC4R function are seen in a modest percentage (5%) of obese adults from various ethnic groups. Children who are affected feel exceedingly hungry and develop obese as a result of their frequent overeating (hyperphagia).

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One obesity subtype is characterised by greater fat mass; the other was characterised by both greater fat mass and lean muscle mass..

Using genome-wide association analyses, researchers discovered the first obesity-related gene variations in the "fat mass and obesity-associated" (FTO) gene on chromosome 16.

These gene variations, however, are relatively "common", the Harvard medical report stated. People who have one have a 20% to 30% greater risk of obesity than those who do not.

Obesity-related gene variant
• Researchers uncovered an obesity-related gene variant on chromosome 18, near the melanocortin-4 receptor gene.

• Across 12 chromosomes, researchers discovered more than 30 candidate genes linked to BMI.

• Even FTO, the most promising of these candidate genes, however, explains only for a modest proportion of the gene-related predisposition to obesity.

But moving from genetic susceptibility to obesity usually necessitates some modification of nutrition, lifestyle, or other environmental factors. Again, the elephant in the room is the environment — the circumstances that determine how much we eat and how active we are.

"Heredity is not always destiny," the Harvard School of Public Health research stated. “Environmental changes that make it easier for people to overeat, and harder for people to get enough physical activity, have played a key role in triggering the recent surge of overweight and obesity."

3. Neuro-developmental factors

A third factor suggested is neuro-developmental, related to the second one. Recently, a team led by Van Andel Institute scientists identified two distinct “sub-types” of obesity in a study.

In their findings, published on September 12, 2022 in the journal Nature Metabolism, researchers sought to redefine and further refine understanding on obesity.

Using a purely data-driven approach, researchers led by J. Andrew Pospisilik, Ph.D., chair of Van Andel Institute's Department of Epigenetics, found that each of metabolic subtypes of obesity has their own physiological and molecular features that influence health.

RDS 190711 CHILD OBESITY-1562775411603
Children who are affected feel exceedingly hungry and develop obese as a result of their frequent overeating (hyperphagia).

One obesity subtype is characterised by "greater fat mass"; the other was characterised by "both greater fat mass and lean muscle mass", the researchers found.

After the two subtypes were identified in the human data, the team then verified the results in lab mice models. The second type also was associated with increased inflammation, which can also elevate the risk of certain cancers and other diseases.

Both subtypes were observed across multiple study subjects, including in children. Interestingly, it also revealed that the second, inflammatory subtype appears to result from changes triggered by “pure chance”, what researchers refer to as "unexplained phenotypic variation" (UPV). Researchers sayd this implies that something else may be in charge of up to 50 per cent of who we are.

According to the study, "epigenetics" (the mechanisms that control when and how the instructions in DNA are used) is likely where the origins of UPV reside.

What is epigenetics?
• “Epi-" means “on or above” in Greek, and "epigenetic" describes factors beyond the genetic code. Epigenetics is the study of how cells control gene activity without changing the DNA sequence.

• In other words, it focuses on the changes in organisms caused by modification of gene expression — a system known as molecular “bookmarking” — rather than alteration of the genetic code itself.

• This “bookmarking” determines which genes will — or will not — be used in different cell types.

• Identical twins offer a good example of epigenetics: Although they share exactly the same DNA, their unique experiences in life will cause some genes (and not others) to express themselves. So, over time, identical twins come to look and behave differently.

Factors that cause rising global “obesidemic”

Genetic changes are unlikely to explain the current global epidemic of obesity. To blame genes alone, or the environment alone, or the neuro-developmental factors alone for this phenomenon misses glaring present-day realities. It's a multi-factorial challenge.

The human "gene pool," or the frequency of different genes in a population, across many generations, has been relatively stable for thousands of years. It takes a long time for new genetic mutations, known as “polymorphisms”, to spread in the human population.

So then if our genes have virtually remained unaltered during the past 50 years amid rising obesity rates, the only thing that has really changed is the easy availability of sugar-packed, high-carb foods, 24-hour TV, gaming, Youtube, and other such "obesidemic" factors.

BMI over the years 1976 to present
Image Credit: WHO

Link to heart disease

Several studies past and present published in high-impact journals --  INTERHEART Study (2004), Framingham study (various phases), Prospective Studies Collaboration (2009) -- point to how obesity contributes to heart disease.

The INTERHEART study, conducted in 52 countries, investigated the role of various risk factors in heart disease, including obesity. It found that abdominal obesity (excess fat around the abdomen) was a strong risk factor for heart attacks, even in individuals who did not have other traditional risk factors such as high cholesterol or hypertension. The results emphasized the significance of central obesity in contributing to heart disease.

Framingham Heart Study (Various Phases) is an ongoing, long-term cardiovascular study that began in 1948 and has provided invaluable insights into heart disease risk factors. One of the key kindings of this stury: Over several decades, the study consistently demonstrated a strong association between obesity and the development of heart disease.

The Prospective Studies Collaboration (2009), on the other hand, provides a meta-analysis that included data from multiple large prospective cohort studies and aimed to quantify the relationship between obesity and cardiovascular mortality. The evidence is robust: obesity was associated with an increased risk of cardiovascular mortality.

More importantly, it shows a direct relationship between body mass index (BMI) and the risk of dying from heart disease. The higher an individual's BMI, the greater their risk of experiencing a fatal heart event.

The latest study published in the peer-reviewed Journal of the American Heart Association earlier this month (September 2023) shows a three-fold increase in obesity-related deaths from heart disease in the US between 1999 and 2020.

Beat the bulge

These studies underline a key challenge: maintaining a healthy weight through diet, exercise, and lifestyle modifications as a key strategy in preventing cardiovascular problems.