Even moderate intake of red meat raises cancer risk: UK Department of Health and Social Care study

London: Eating even the moderate amounts of red and processed meat sanctioned by British government guidelines increases the likelihood of developing bowel cancer, according to the largest UK study of the risks ever conducted.

The Department of Health and Social Care (DHSC) suggests anyone who eats more than 90g of red or processed meat per day should try to cut down to 70g or less, because of the known link with bowel cancer. The NHS describes 90g of red meat as “equivalent to around three thinly cut slices of beef, lamb or pork, where each slice is about the size of half a piece of sliced bread”.

Processed meat includes sausages, bacon and ham. A cooked breakfast with two “typical British” sausages and two rashers of bacon would clock up 130g, the NHS advises.

Meat is important for iron ... The main message for the public is that it reinforces the government advice that we shouldn’t eat large amounts of red and processed meat.

- Professor Tim Key | Study author

A five-year study of half a million men and women who have signed up to the UK Biobank research project found those who were more or less keeping to the guidelines, eating on average 76g of red or processed meat per day, had a 20 per cent increased risk of bowel cancer compared with those who averaged 21g a day.

The risk increased by 20 per cent with each extra slice of ham or rasher of bacon (roughly 25g) the study participants ate, and by 19 per cent with each thick slice of roast beef or the edible part of a lamb cutlet (about 50g).

The study also found heavier drinkers of alcohol had an increased risk - up by 24 per cent among those who drank the most alcohol compared with those who drank the least. Eating fibre in the form of breakfast cereals and bread had a protective effect, however. In January, a study commissioned by the World Health Organisation (WHO) reported fibre also protects against heart disease.

Cancer Research UK’s expert in diet and cancer, Prof Tim Key, who co-authored the study and is also deputy director at the University of Oxford’s cancer epidemiology unit, said the research had an extra adjustment to check whether participants had accurately reported what they eat. Diet studies are problematic because those who take part often either forget what they have eaten or fail to tell the truth.

All the Biobank participants were asked about their diet when they joined up. In this study, they were also asked to complete an additional questionnaire every three or four months, detailing exactly what they had eaten in the previous 24 hours.

The researchers found those who ate the most and least red and processed meat tended to exaggerate their consumption or lack thereof. That led to a steeper increase in risk than in studies relied on by the WHO when it produced the guidance incorporated into that of the DHSC.

“We are not claiming that therefore the government recommendation is wrong and should be changed,” Key said. The paper, published in the International Journal of Epidemiology, would have to be seen in the context of many others, he said.

Key also said meat had nutritional benefits. “Meat is important for iron. We would want to consider other aspects of health if we were going to change the recommendation. The main message for the public is that it reinforces the government advice that we shouldn’t eat large amounts of red and processed meat,” he said.

Alcohol, on the other hand, increased bowel cancer risk and did not have nutritional benefits, he said. “Alcohol is an optional thing that we don’t have to consume,” Key added.

Dr Gunter Kuhnle, an associate professor in nutrition and health at Reading University, said the analysis of the link between meat intake and bowel cancer was very thorough and confirmed previous findings about the risks.

“The results of this study also question the recent focus on nitrite as the main culprit for colorectal cancer: the authors found very small differences between red and processed meat in this study, even though only processed meat contains nitrite,” he said.

“A reduction or removal of nitrite from meat products would therefore have only little impact on cancer risk. An increased consumption of fibre, as shown by this study, would be of considerably more benefit.”

Dr Julie Sharp, Cancer Research UK’s head of health information, said: “The government guidelines on red and processed meat are general health advice and this study is a reminder that the more you can cut down beyond this, the more you can lower your chances of developing bowel cancer.”

Point of view: Diet is the key

By Dr Arun Karanwal | Specialist Medical Oncologist at the Prime Hospital, Dubai

Over the years there have been several studies indicating a direct correlation of red meat to colorectal cancers. Although It has not been established that red meat itself contains carcinogens, but the chemical additives used in processing the meat do have cancer-causing compounds. Heavy consumption of red meat does trigger indigestion and constipation which are triggers for bowel cancer. The odds of cancer double in people consuming large portions of red meat compared to vegetarians or those who avoid red meat.

While it may not be possible to eliminate red meat or alter one’s lifestyle moderation holds the key.

All international health guidelines from bodies such as the American Heart Association, and American Cancer Association advise combining large portion of raw fruits, vegetables and sprouts to add anti-oxidants and high fibre to our meals. Red meat contains nitrites which are oxidants which trigger the carcinogenic process with oxidation. Having at least one portion of fruit, raw vegetables, herbs and leaves can counter the carcinogens and oxidative elements in red meat.