UK COVID-19 variant is probably deadlier, scientists say

London: British government scientists are increasingly finding the coronavirus variant first detected in Britain to be deadlier than the original virus, a devastating trend that highlights the serious risks of this new phase of the pandemic.

The scientists said last month that there was a "realistic possibility" that the variant was more lethal. Now, they say in a new document that it is "likely" that the variant is connected to an increased risk of hospitalization and death.

The British government did not publicly announce the updated findings, which are based on roughly twice as many studies as their earlier assessment and include more deaths from cases of COVID-19 caused by the new variant, known as B.1.1.7. It posted the document on a government website Friday and said that it had been considered at a meeting of government advisers the day before.

The variant is known to be in 82 countries, including the United States. American scientists recently estimated that it was spreading rapidly there, doubling roughly every 10 days, and have said that it could be the dominant version of the virus in the United States by March.

"Calculating when we can lift restrictions has to be influenced by this," Simon Clarke, an associate professor in cellular microbiology at the University of Reading, said of the new findings. "It provides extra evidence that this variant is more lethal than the one we dealt with last time."

Most COVID-19 cases, even those caused by the new variant, are not fatal. And the government scientists were relying on studies that examined a small proportion of overall deaths, making it difficult to pinpoint how much increased risk may be associated with the new variant.

But the strongest studies they relied on estimated that the variant could be 30% to 70% more lethal than the original virus.

And the government scientists, part of a committee known as the New and Emerging Respiratory Virus Threats Advisory Group, wrote that the latest studies had helped them control for factors such as the influence of overrun hospitals.

That, they said, allowed for "increasing confidence in the association" of the new variant "with increased disease severity."

The variant is thought to be 30% to 50% more transmissible than the original virus, though some scientists now believe it is even more contagious than that. The first sample of the variant was collected in southeastern England in September, and it quickly became the dominant version of the virus in Britain. It now accounts for more than 90% of cases in many parts of the country.

As it spread, hospitals became overwhelmed by the pace of new infections, with doctors and nurses treating nearly twice as many hospitalized patients as they did during last year's peak. A stringent lockdown has since sharply driven down the number of new coronavirus cases in Britain.

As an example of the mounting evidence for the variant's lethality, the government scientists cited a study from the London School of Hygiene and Tropical Medicine. In January, that study examined the deaths of 2,583 people, 384 of whom were believed to have had cases of COVID-19 caused by the new variant. The research estimated that people infected with the new variant had a 35% higher risk of dying.

An updated study by the same group relied on 3,382 deaths, 1,722 of which were believed to be from the new variant. That study suggested that the variant could be connected with a 71% higher risk of dying.

Clarke said the new findings vindicated the British government's decision to raise an alarm about the variant in December and then publish evidence last month that it was potentially more lethal. Some outside scientists initially dismissed the warnings.

"They didn't hold the data back," Clarke said. "They were very upfront about how uncertain things were."