New York: The coronavirus has killed so many people in Iran that the country has resorted to mass burials, but in neighbouring Iraq, the body count is fewer than 100.
The Dominican Republic has reported nearly 7,600 cases of the virus. Just across the border, Haiti has recorded about 85.
In Indonesia, thousands are believed to have died of the coronavirus. In nearby Malaysia, a strict lockdown has kept fatalities to about 100.
The coronavirus has touched almost every country on earth, but its impact has seemed capricious. Global metropolises like New York, Paris and London have been devastated, while teeming cities like Bangkok, Baghdad, New Delhi and Lagos have, so far, largely been spared.
Puzzle has spawned numerous theories
The question of why the virus has overwhelmed some places and left others relatively untouched is a puzzle that has spawned numerous theories and speculations but no definitive answers. That knowledge could have profound implications for how countries respond to the virus, for determining who is at risk and for knowing when it’s safe to go out again.
There are already hundreds of studies underway around the world looking into how demographics, preexisting conditions and genetics might affect the wide variation in impact.
Doctors in Saudi Arabia are studying whether genetic differences may help explain varying levels of severity in COVID-19 cases among Saudis, while scientists in Brazil are looking into the relationship between genetics and COVID-19 complications. Teams in multiple countries are studying if common hypertension medications might worsen the disease’s severity and whether a particular tuberculosis vaccine might do the opposite.
Are temperature and demographics factors?
Many developing nations with hot climates and young populations have escaped the worst, suggesting that temperature and demographics could be factors. But countries like Peru, Indonesia and Brazil, tropical countries in the throes of growing epidemics, throw cold water on that idea.
Draconian social distancing and early lockdown measures have clearly been effective, but Myanmar and Cambodia did neither and have reported few cases.
One theory that is unproven but impossible to refute: Maybe the virus just hasn’t gotten to those countries yet. Russia and Turkey appeared to be fine until, suddenly, they were not.
Time may still prove the greatest equaliser: The Spanish flu that broke out in the United States in 1918 seemed to die down during the summer only to come roaring back with a deadlier strain in the fall and a third wave the following year. It eventually reached far-flung places like islands in Alaska and the South Pacific and infected a third of the world’s population.
“We are really early in this disease,” said Dr. Ashish Jha, director of the Harvard Global Health Research Institute. “If this were a baseball game, it would be the second inning, and there’s no reason to think that by the ninth inning the rest of the world that looks now like it hasn’t been affected won’t become like other places.”
Not enough data
Doctors who study infectious diseases around the world say they do not have enough data yet to get a full epidemiological picture, and that gaps in information in many countries make it dangerous to draw conclusions. Testing is woeful in many places, leading to vast underestimates of the virus’s progress, and deaths are almost certainly undercounted.
Still, the broad patterns are clear. Even in places with abysmal record-keeping and broken health systems, mass burials or hospitals turning away sick people by the thousands would be hard to miss, and a number of places are just not seeing them - at least not yet.
Interviews with more than two dozen infectious disease experts, health officials, epidemiologists and academics around the globe suggest four main factors that could help explain where the virus thrives and where it doesn’t: demographics, culture, environment and the speed of government responses.
Each possible explanation comes with considerable caveats and confounding counterevidence. If an aging population is the most vulnerable, for instance, Japan should be at the top of the list. It is far from it. Nonetheless, these are the factors that experts find the most persuasive.
Many countries that have escaped mass epidemics have relatively younger populations.
Young people are more likely to contract mild or asymptomatic cases that are less transmissible to others, said Robert Bollinger, a professor of infectious diseases at the Johns Hopkins School of Medicine. And they are less likely to have certain health problems that can make COVID-19, the disease caused by the coronavirus, particularly deadly, according to the World Health Organization.
Africa - with about 45,000 reported cases, a tiny fraction of its 1.3 billion people - is the world’s youngest continent, with more than 60% of its population under age 25. In Thailand and Najaf, Iraq, local health officials found that the 20-to-29 age group had the highest rate of infection but often showed few symptoms.
By contrast, the national median age in Italy, one of the hardest-hit countries, is more than 45. The average age of those who died of COVID-19 there was around 80.
Younger people tend to have stronger immune systems, which can result in milder symptoms, said Josip Car, an expert in population and global health at Nanyang Technological University in Singapore.
There are notable exceptions to the demographic theory. Japan, with the world’s oldest average population, has recorded fewer than 520 deaths, although its caseload has risen with increased testing.
The Guayas region of Ecuador, the epicentre of an outbreak that may have claimed up to 7,000 lives, is one of the youngest in the country, with only 11% of its residents over 60 years old.
And Jha of Harvard warns that some young people who are not showing symptoms are also highly contagious for reasons that are not well understood.
Cultural factors, like the social distancing that is built into certain societies, may give some countries more protection, epidemiologists said.
In Thailand and India, where virus numbers are relatively low, people greet each other at a distance, with palms joined together as in prayer. In Japan and South Korea, people bow, and long before the coronavirus arrived, they tended to wear face masks when feeling unwell.
In much of the developing world, the custom of caring for the elderly at home leads to fewer nursing homes, which have been tinder for tragic outbreaks in the West.
However, there are notable exceptions to the cultural-distancing theory. In many parts of the Middle East, such as Iraq and the Gulf countries, men often embrace or shake hands on meeting, yet most are not getting sick.
The geography of the outbreak - which spread rapidly during the winter in temperate-zone countries like Italy and the United States and was virtually unseen in warmer countries such as Chad or Guyana - seemed to suggest that the virus did not take well to heat. Other coronaviruses, such as ones that cause the common cold, are less contagious in warmer, moist climates.
But researchers say the idea that hot weather alone can repel the virus is wishful thinking.
Some of the worst outbreaks in the developing world have been in places like the Amazonas region of Brazil, as tropical a place as any.
“The best guess is that summer conditions will help but are unlikely by themselves to lead to significant slowing of growth or to a decline in cases,” said Marc Lipsitch, director of the Centre for Communicable Disease Dynamics at Harvard University.
The virus that causes COVID-19 appears to be so contagious as to mitigate any beneficial effect of heat and humidity, said Dr. Raul Rabadan, a computational biologist at Columbia University.
But other aspects of warm climates, like people spending more time outside, could help.
“People living indoors within enclosed environments may promote virus recirculation, increasing the chance of contracting the disease,” said Car of Nanyang Technological University.
The ultraviolet rays of direct sunlight inhibit this coronavirus, according to a study by ecological modelers at the University of Connecticut. So surfaces in sunny places may be less likely to remain contaminated, but transmission usually occurs through contact with an infected person, not by touching a surface.
Countries that locked down early, like Vietnam and Greece, have been able to avoid out-of-control contagions, evidence of the power of strict social distancing and quarantines to contain the virus.
In Africa, countries with bitter experience with killers like HIV, drug-resistant tuberculosis and Ebola knew the drill and reacted quickly.
Airport staff from Sierra Leone to Uganda were taking temperatures (since found to be a less effective measure) and contact details and wearing masks long before their counterparts in the United States and Europe took such precautions.
Senegal and Rwanda closed their borders and announced curfews when they still had very few cases. Health ministries began contact tracing early.
All this happened in a region where health ministries had come to rely on money, personnel and supplies from foreign donors, many of which had to turn their attention to outbreaks in their own countries, said Catherine Kyobutungi, executive director of the African Population and Health Research Center.
“Countries wake up one day, and they’re like, ‘OK, the weight of the country rests on our shoulders, so we need to step up,’” she said. “And they have. Some of the responses have been beautiful to behold, honestly.”
Counterintuitively, some countries where authorities reacted late and with spotty enforcement of lockdowns appear to have been spared. Cambodia and Laos both had brief spates of infections when few social distancing measures were in place, but neither has recorded a new case in about three weeks.
Lebanon, whose Muslim and Christian citizens often go on pilgrimages respectively to Iran and Italy, places rife with the virus, should have had high numbers of infections. It has not.
“We just didn’t see what we were expecting,” said Dr. Roy Nasnas, an infectious disease consultant at the University Hospital Geitaoui in Beirut. “We don’t know why.”
Combination of the above factors
Finally, most experts agree that there may be no single reason for some countries to be hit and others missed. The answer is likely to be some combination of the above factors as well as one other mentioned by researchers: sheer luck.
Countries with the same culture and climate could have vastly different outcomes if one infected person attends a crowded social occasion, turning it into what researchers call a superspreader event.
Too little testing
And when countries do all the wrong things and still end up seemingly not as battered by the virus as one would expect, go figure.
“In Indonesia, we have a health minister who believes you can pray away COVID, and we have too little testing,” said Dr. Pandu Riono, an infectious disease specialist at the University of Indonesia. “But we are lucky we have so many islands in our country that limit travel and maybe infection.
“There’s nothing else we’re doing right,” he added.