City mayor Menderes Turel told the broadcaster NTV that "10 to 12 people were slightly injured by flying glass" in the explosion at the Antalya Chamber of Commerce and Industry building.
The blast occurred at 8.50am (0550 GMT, 9.50am Dubai).
Turel told CNN Turk channel the blast was being investigated and it was "too early" to make assumptions as to the cause.
"The blast may not be a terror attack... we must wait for official information," Turel said.
Over the past year, Turkey has suffered a series of attacks blamed on the Daesh group and Kurdish militants.
TV images showed a wrecked, burned-out car and smashed glass nearby. At least four cars nearby were also damaged, Dogan news agency said.
The incident occurred 11 days after three rockets hit a roadside fishmonger in the popular tourist region, but without causing casualties.
In Antalya, Turkey, an explosion occurred https://t.co/q0iEy7reOL pic.twitter.com/WO1pZGGlRY #news #Russia— Rus to En Fr Es News (@Rus_Eng_News) October 25, 2016