Novak Djokovic held off a gallant challenge from Karen Khachanov in front of a capacity crowd on Wednesday to win 6-3, 7-6 and reach the quarter-finals of the Dubai Duty Free Tennis Championships.
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Earlier, Jannik Sinner denied Andy Murray his 700th career victory when he defeated the former world No. 1 7-5, 6-2.
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The Scotsman missed out on his 700th ATP win and will have to wait to reach that landmark.
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Second seed Andrey Rublev also advanced to the quarter-finals, but he was challenged well by Soonwoo Kwon before winning 4-6, 6-0, 6-3.
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He will face Mackenzie McDonald for a place in the semi-finals after the American followed up his first-round victory over defending champion Aslan Karatsev by defeating Filip Krajinovic 6-4, 7-6.
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In other second round matches, qualifier Jiri Vesely beat eighth seed and former Dubai champion Roberto Bautista Agut 6-2, 6-4 to set up a clash with Djokovic.
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Fifth seed Hubert Hurkacz defeated Alex Molcan 6-3 6-2, and is up against Sinner next.
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Sixth seed Denis Shapovalov ended the run of qualifier Taro Daniel 6-4 6-3. He will next play qualifier Ricardas Berankis who won 6-4, 7-6 against Alexei Popyrin.
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