Dharamsala: Ravichandran Ashwin took five wickets in his landmark 100th Test as India hammered England by an innings and 64 runs in the fifth match to seal the series 4-1 on Saturday.
Off-spinner Ashwin returned figures of 5-77 to help bowl out England for 195 in the tourists' second innings, the match ending inside three days in Dharamsala.
England captain Ben Stokes fell on the stroke of lunch with the tourists still 156 runs behind.
Joe Root was batting on 34 but England's lower order will have to bat out of their skin to deny India an innings victory at the picturesque Himachal Pradesh Cricket Association Stadium.
Earlier resuming on 473-8, India could add only four runs before losing their last two wickets.
England warhorse James Anderson became the first fast bowler to claim 700 test wickets when he dismissed Kuldeep Yadav (30) caught behind.
The travelling "Barmy Army" fans gave Anderson a standing ovation but their morale sagged soon after England walked out to bat, having conceded a significant first-innings lead of 259.
India harnessed Ravichandran Ashwin with Jasprit Bumrah for new ball duties, and the off-spinner bowled Ben Duckett (two) in his first over.
The opener had charged so far down the track that he would have been stumped even if he was not bowled.
Ashwin struck again in this third over, dismissing Zak Crawley for a duck.
Crawley, England's leading scorer in the series, could only turn the ball to Sarfaraz Khan at backward short leg.
Ollie Pope made a breezy 19 before attempting a sweep against Ashwin, and Yashasvi Jaiswal took a running catch to dismiss the England vice captain.
Jonny Bairstow smacked Ashwin for three sixes in an enthralling duet between two fierce competitors both playing their 100th test.
Kuldeep Yadav, replacing Ashwin in the attack, ended Bairstow's entertaining knock of 39, trapping him lbw.
Ashwin returned to disturb Stokes' stumps with the final delivery before the lunch break.
