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Star director James Cameron, who stunned critics and audiences alike with his fantasy world in Avatar, picked up the award for Best Director. Accepting his award, Canadian Cameron spoke in Na'vi the language of the people of Pandora in Avatar's fictional world saying: "Thank you my brother and my sister." Image Credit: AP

Beverly Hills: James Cameron has won the best-director Golden Globe for his science-fiction blockbuster “Avatar.”

Among acting winners are Meryl Streep in “Julie & Julia,” Mo'Nique as a loathsome, abusive welfare mother in “Precious” and Christoph Waltz as a gleefully bloodthirsty Nazi in “Inglourious Basterds.”

Globe wins could boost recipients' prospects at the Oscars, whose nominations balloting closes Saturday.

In Pictures: Click here to see who won (and for what)

In Pictures: Click here to see red carpet fashion

Cameron’s Avatar

James Cameron's sci-fi epic “Avatar” came in with four nominations but lost its first two categories, for song and musical score. Cameron's tale - which has soared up the box-office charts with $1.6 billion worldwide, second only to his own “Titanic” at $1.8 billion - had to wait until the end of the show for its next categories, best director and drama.

Liftime for Scorsese

Martin Scorsese has been honoured with the Cecil B. DeMille Award for lifetime achievement at the Golden Globes.

Two of his most frequent stars, actors Robert De Niro and Leonardo DiCaprio, presented the award at the Sunday night ceremony at the Beverly Hilton Hotel, in Beverly Hills, California.

Though Scorsese's 2007 Oscar win for directing “The Departed” was a longtime coming, he has had better success at the Globes.

Julie & Julia

Meryl Streep won the Golden Globe for best musical or comedy actress as chef Julia Child in “Julie & Julia” on Sunday, while supporting honours went to Mo'Nique for “Precious” and Christoph Waltz for “Inglourious Basterds.”

The blockbuster “Up” came away with the award for animated film.

* See the full list of this year's Golden Globe winners

While Streep is a perennial at awards shows, the prize marked a dramatic turning point for Mo'Nique, who was mainly known for lowbrow comedy but startled audiences with her ferocious performance in “Precious: Based on the Novel 'Push' By Sapphire.” Mo'Nique plays a loathsome, abusive welfare mother.

“First let me say, thank you, God, for this amazing ride that you're allowing me to go on,” the tearful Mo'Nique told the crowd.

She went on with gushing praise for “Precious” director Lee Daniels and newcomer Gabourey Sidibe, a best dramatic actress nominee at the Globes with her first film role, playing Mo'Nique's abused, illiterate daughter.

“Lee Daniels, the world gets a chance to see how brilliant you are. You are a brilliant, fearless, amazing director who would not waver, and thank you for trusting me,” Mo'Nique said. “To Gabby, sister, I am in awe of you. Thank you for letting me play with you.”

Streep's competition for best actress in a musical or comedy included herself. She also was nominated for the romance “It's Complicated.”

“I just want to say that in my long career, I've played so many extraordinary woman that I'm getting mistaken for one,” Streep said. “I'm very clear that I'm the vessel for other people's stories and other people's lives.”

Inglourious Basterds

Waltz, a veteran Austrian actor who is a relative newcomer in Hollywood, won the supporting-actor Globe as a gleefully bloodthirsty Nazi in Quentin Tarantino's “Inglourious Basterds.”

“A year and a half ago I was exposed to the gravitational forces of Quentin Tarantino,” Waltz said. “He took my modest little world, my globe, and with the power of his talent and his words and his vision, he flung it into its orbit, a dizzying experience.”

The Globes were a mix of far-out fantasy and ripped-from-the-headlines reality at the Golden Globes, Hollywood's first major film honours that will help sort out the Oscar picture.

Contenders for best drama include two wildly make-believe adventures, the science-fiction spectacle “Avatar” and “Inglourious Basterds,” which rewrites the end of World War II with a gleefully vengeful bloodbath at a movie premiere.

Also competing are timely dramas of the war on terror (“The Hurt Locker”) and economic hard times (“Up in the Air”), along with the grim but inspiring “Precious,” with Sidibe as a Harlem teen struggling to lift herself out of an abyss of neglect.

Though one of Hollywood's biggest parties, the Globes bore sombre reminders of tragedy in the real world, many stars wearing ribbons in support of earthquake victims in Haiti.

Films from Pixar Animation, the Disney outfit that made “Up,” have won all four prizes for animated movies since the Globes introduced the category in 2006. Past Pixar winners are “WALL-E,” “Ratatouille” and “Cars.”

“Up” features the voice of Ed Asner in a tale of a lonely, bitter widower who renews his zest for adventure by flying his house off under helium balloons to South America, where he encounters his childhood hero and a hilarious gang of talking canines.

“When it came to finding the heart of the film, we didn't have to look very hard,” said “Up” director Pete Docter, whose film also won for musical score. “Our inspiration was all around us. Our grandparents, our parents, our wives, our kids. Our talking dogs.”

Jason Reitman and Sheldon Turner won the screenplay honour for “Up in the Air,” which Reitman also directed. The foreign-language honour went to “The White Ribbon,” a stark drama of guilt and suspicion set in a German town on the eve of World War I.

The song prize went to “The Weary Kind” from the country-music drama “Crazy Heart.”

“Mad Men” won for best TV drama, while Michael C. Hall won for best actor in a TV drama for “Dexter,” in which he plays a serial killer with a code of ethics, killing only other murderers. Hall's publicists revealed this past week that Hall is being treated for Hodgkin's lymphoma and that the cancer is in remission.

“It's really a hell of a thing to go to work in a place where everybody gives a damn. That's really the case with `Dexter,”' Hall said. “It's a dream job. I'm so grateful.”

“Dexter” also won the supporting-actor TV honour for John Lithgow. Other TV winners included Juliana Margulies as best actress in a drama for “The Good Wife” and Toni Collette as best comedy actress for “The United States of Tara.”

The rain-drenched red carpet was a rare sight for an awards show in sunny southern California, stars in their finery getting damp under umbrellas as storms swept the region.

The Globes got a makeover, featuring Ricky Gervais as master of ceremonies, the first time in 15 years the show had a host.

Martin Scorsese, who won the best-director Globe three years ago for “The Departed,” is receiving the Cecil B. DeMille Award for career achievement.

Sunday's winners could get a last-minute boost for the Oscars, whose nominations balloting closes Saturday. Last year's big Globe winner, “Slumdog Millionaire,” went on to dominate the Oscars.

The Globes are presented by the Hollywood Foreign Press Association, a group of about 90 reporters covering show business for overseas outlets. The show airs live on NBC.