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Smoke raises from the Defence Ministry's compound after an attack, in Sanaa on December 5 in this file photo. Image Credit: Reuters

Sana’a: A suicide car bombing at the defence ministry in the heart of Sana'a on Thursday killed at least two and left 20 wounded, many seriously, Yemeni security sources said.

"A car bomb driven by a suicide bomber tried to force its way into the western entrance of the ministry complex," a security official said.

"It was followed by another car whose occupants opened fire at the complex of buildings," he said.

"There are dead and wounded," another security source said after a strong explosion was heard across the capital, without giving any immediate figures.

Plumes of smoke billowed across the complex, situated on the edge of the Baba al-Yaman neighbourhood, and gunfire was heard.

The bombing comes at a time when Yemen is experiencing a surge of violence, and follows a spate of hit-and-run attacks on military and other officials in Sanaa by militants on motorbikes.

The attacks in the capital and in the country's south have been blamed on Al-Qaeda in the Arabian Peninsula (AQAP), which Washington regards as the jihadist network's most dangerous branch.

Yemen has been going through a difficult political transition since veteran president Ali Abdullah Saleh was ousted in February 2012 after a year of deadly protests against his 33-year rule.