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It was a grand Hollywood romance that made its presence felt far and wide, from the red carpet to refugee camps in the world’s trouble spots.

It was chronicled in lavish photo spreads in high-end fashion magazines and in paparazzi shots that appeared in the tabloids and on the gossip sites, as if to undercut the couple’s mythic status.

Now, with a lawyer’s blandly worded press statement on Tuesday morning, the love story of Angelina Jolie Pitt and Brad Pitt, who were married in 2014, has come to an unhappy end.

“This decision was made for the health of the family,” Robert Offer, a lawyer for Jolie Pitt, said in the statement. “She will not be commenting, and asks that the family be given its privacy at this time.”

The announcement came a little over two years after the couple married in a ceremony before roughly 20 friends and family members in a Romanesque chapel on the grounds of Chateau Miraval, their estate in the South of France. The couple’s six children, three of them adopted, attended the bride and groom. Master tailor Luigi Massi of Atelier Versace made Jolie Pitt’s wedding dress, incorporating designs from her children’s drawings.

In keeping with the public nature of their relationship, Pitt and Jolie Pitt sold the photographs of their wedding day to People and Hello! magazines for a reported $5 million (Dh18.36 million). In keeping with their habit of giving to charity, the couple contributed the payment to the Jolie-Pitt Foundation.

When their romance became public, the tabloids were quick to dub them “Brangelina.” At the time, she was a divorced mother of an adopted son, Maddox, having ended her marriage to actor Billy Bob Thornton in 2003. Pitt was still married to Friends star Jennifer Aniston.

Aniston filed for divorce from the actor in March 2005. That summer a spread appeared in the large-format glossy magazine W. Shot by Steven Klein and headlined Domestic Bliss: Angelina Jolie and Brad Pitt at Home, it comprised 60 pages of photographs of Pitt, Jolie and five boys (all of them models) who somewhat resembled Pitt, in a chic, early 1960s setting.

Their most recent project as a couple, the 2015 film By the Sea, directed by Jolie Pitt, told a different story. “Meta with a vengeance, By the Sea stars Angelina Jolie Pitt and Brad Pitt as itinerant married artists who are suffering, beautifully, through a rough patch,” wrote Manohla Dargis in her review for The New York Times.

Asked about the process of directing her husband, Jolie Pitt told Vanity Fair, “A few friends asked if we were crazy.” The moody film was a box-office flop, grossing $3.3 million.

During the course of their relationship, the Jolie-Pitt clan expanded. In addition to Maddox, 15, whom Jolie adopted in Cambodia in 2002, the couple are parents to Zahara, 11, from Ethiopia; Shiloh, to whom Jolie gave birth in Namibia in 2006; Pax, 12, adopted in Vietnam; and twins Vivienne and Knox, 8, to whom Jolie gave birth in 2008.

Pitt and Jolie Pitt have separately discussed struggling with self-destructive behaviour in their younger years. Both seemed to have overcome the dark periods, with a slew of high grossing, critically acclaimed films to their names and a well-documented commitment to philanthropy.

She began working for the United Nations in 2000 as a goodwill ambassador, and became the special envoy for the UN High Commissioner for Refugees in 2012.

She has gone on dozens of missions to countries around the world, including Iraq, Jordan and Myanmar. Last year she addressed the UN Security Council, arguing that the UN was failing the people of Syria. Earlier this month Jolie Pitt spent three days at the Azraq camp in Jordan, which is home to more than 37,000 Syrian refugees, according to the UN.

During her years with Pitt, she had box office hits with the action movie Wanted and the Disney fantasy Maleficent while also making a name for herself as a director of serious fare like In the Land of Blood and Honey, a love story set against the backdrop of the Bosnian War, and Unbroken.

He has won an Oscar for producing the critically acclaimed 12 Years a Slave and has been nominated for several other Oscars, including for best actor for The Curious Case of Benjamin Button and for Moneyball. He was also nominated for a best supporting actor Golden Globe for his role in Babel.

In 2013 Jolie wrote a candid and widely praised Op-Ed page essay for The New York Times about choosing to have a preventive double mastectomy. She followed it up in 2015 with an essay on her next preventive surgery, during which her ovaries and fallopian tubes were removed.

While he wears his political commitments more lightly than Jolie Pitt, Pitt is a co-founder of Not on Our Watch, a non-governmental organisation devoted to preventing genocide, and the founder of Make It Right, which builds homes and other structures for people in need.

During their time together, the couple demonstrated an unusual ability to negotiate with the media. After Shiloh was born in 2006, the couple sold photos of the mother and newborn to People magazine for an estimated $4.1 million, all of which they donated to charity. That same year they negotiated with People on another deal, giving the magazine exclusive photos of Jolie and Maddox for an estimated $750,000 and the promise to cover Jolie’s charity work.

Later, they received an estimated $14 million from People and Hello! magazines — for shots of their twins — and again donated the funds to charity.

On Tuesday, with the announcement of the split, the hashtag #Brangelina quickly became the top trending item on Twitter, with fans reacting to the news with a range of emotions, including laments over the death of love; complaints that the news was superseding President Barack Obama’s speech at the United Nations; and theories that the news was a welcome distraction from the presidential campaign.

Jolie Pitt was silent on the matter but Pitt gave a statement to People magazine: “I am very saddened by this but what matters most now is the well-being of our kids. I kindly ask the press to give them the space they deserve during this challenging time.”