Yangon, Myanmar: A senior US State Department official has held high-profile talks with Myanmar's detained opposition leader Aung San Suu Kyi, as the Obama administration opens a new era of engaging the country's military rulers.

US Embassy spokesman Richard Mei says Assistant Secretary of State Kurt Campbell, the top US diplomat for East Asia, greeted Suu Kyi Tuesday with a handshake after she was driven to his lakeside luxury hotel in Yangon.

The topic of their discussion was not immediately known but the meeting offered Suu Kyi, her first trip in years outside the confines of her dilapidated home and Myanmar's notorious Insein Prison.

The 64-year-old Nobel Peace Prize laureate has been detained for 14 of the past 20 years, mostly under house arrest.