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A Kyrgyz opposition activist throws a projectile at riot police during an anti-government protest in Bishkek on April 7, 2010. Opposition followers killed Kyrgyzstan's interior minister, took the deputy prime minister hostage and captured state television in a deadly revolt against President Kurmanbek Bakiyev. Image Credit: AFP

Bishek: The opposition seized Kyrgyzstan's government headquarters Thursday following clashes between protesters and security forces that have left 68 people dead nationwide, and appeared to control this Central Asian country that houses a key US air base.

No police guarded the government headquarters, and hundreds of jubilant but calm residents stood outside, including some who had climbed up on an armored personnel carrier.

Others were walking freely through the building known as the White House.

Scars of Wednesday's fighting, though, were everywhere in the capital, Bishkek, and the Health Ministry said the death toll rose overnight to 68, with 400 people still hospitalized.

The numbers included those killed or wounded in clashes elsewhere in the country as protesters drove out local governments.

President Kurmanbek Bakiyev, who came to power in a similar popular uprising five years ago, was said to have fled to the southern city of Osh, and it was difficult to gauge how much of the impoverished, mountainous country the opposition controlled.

Opposition leader Rosa Otunbayeva, a former foreign minister who has declared herself head of an interim government, was to address parliament Thursday morning.

The opposition has called for the closure of the US air base in Manas outside the capital, which is an essential transit point for supplies essential to the war in nearby Afghanistan.

US military officials said Kyrgyzstan officials halted flights for 12 hours on Wednesday at the Manas air base, but the suspension was not expected to impact military operations because fewer flights were scheduled during overnight hours.

Some semblance of order returned to Bishkek, where until the early hours of the morning gunfire could be heard as marauding, looting mobs rampaged through the city.

Almost no government building was left untouched. Some were set on fire or had windows smashed. A three-story Chinese trading house was ablaze Thursday. The state TV channel was overrun and looted.

On Wednesday, protesters who were called into the streets by opposition parties stormed government buildings in Bishkek and battled with police amid volleys of tear gas. Groups of elite officers then fired with live ammunition.

After nightfall, the opposition and its supporters appeared to gain the upper hand.

An AP reporter saw opposition leader Keneshbek Duishebayev sitting in the office of the chief of the National Security Agency, Kyrgyzstan's successor to the Soviet KGB. Duishebayev issued orders on the phone to people he said were security agents, and he also gave orders to a uniformed special forces commando.

Duishebayev, the former interior minister, told the AP that "we have created units to restore order" on the streets. Many of the opposition leaders were once allies of Bakiyev, in some cases former ministers or diplomats.

Since coming to power in 2005 amid street protests known as the Tulip Revolution, Bakiyev had ensured a measure of stability in the country of 5 million people, but the opposition says he has done so at the expense of democratic standards while enriching himself and his family.

He gave his relatives, including his son, top government and economic posts and faced the same accusations of corruption and cronyism that led to the ouster of his predecessor, Askar Akayev.

In the past two years, authorities have clamped down on the media, and opposition activists say they have routinely been subjected to physical intimidation and targeted by politically motivated criminal investigations.

Like its neighbors Uzbekistan and Tajikistan, Kyrgyzstan has remained impoverished since the 1991 collapse of the Soviet Union and has a history of stifling democratic institutions and human rights.

Kyrgyzstan is a predominantly Muslim country, but just as in Soviet times, it has remained secular. There has been little fear of the spread of Islamic fundamentalism as in other mostly Muslim regions of the former Soviet Union.

Russian Prime Minister Vladimir Putin denied any involvement in the uprising.

"Russian officials have absolutely nothing to do with this," he said in Smolensk in response to a journalist's question. "Personally, these events caught me completely by surprise."

He also criticized Bakiyev's government for repeating Akayev's mistakes.

"When President Bakiyev came to power, he was very harshly critical of the fact that the relatives of the deposed President Akayev had taken positions throughout Kyrgyzstan's economy. I have the impression that Mr. Bakiyev is stepping on these same rakes."

A senior US official, speaking on condition of anonymity due to the uncertainty and delicacy of the situation, said the US was in touch with government officials and the opposition.

"We want to see the situation resolved peacefully, consistent with the rule of law," the official said.

"Our conversation with the opposition at this stage is about finding out what is happening and encouraging a peaceful resolution."

The anti-government forces were in disarray until recent widespread anger over the 200 percent increase in electric and heating bills unified them and galvanized support.

Many of Wednesday's protesters were men from poor villages, including some who had come to the capital to live and work on construction sites.

Already struggling, they were outraged by the high cost of energy and were easily stirred up by opposition claims of official corruption.

In Washington, State Department spokesman P.J. Crowley said the US deplored the violence and urged all to respect the rule of law.

"We identify with the concerns that the people of Kyrgyzstan have about their future," but those concerns should be dealt with peacefully, Crowley said, adding that the Manas base was operating normally.