Ankara: Turkey’s state-run news agency says US-led coalition air strikes and Turkish artillery fire against Daesh group in Syria have killed 104 militants.

Anadolu Agency says on Saturday said the strikes came late Friday, hours after rockets fired from Syria hit a southern Turkish town and wounded five people.

It said the air strikes and artillery fire also destroyed 7 buildings used as Daesh headquarters. The claim could not be independently verified, and Turkey has not explained how it can count casualties in Syria.

Cross-border fire from Syria has claimed 21 lives and wounded dozens of others in the border town of Kilis this year.

Authorities blame the attacks on Daesh which has a presence in northern Syria. Turkey typically responds by shelling Daesh positions.

Meanwhile Daesh militants entered a Syrian opposition stronghold in the country’s north on Saturday, clashing with rebels on the edges of the town as the extremist group built on its most significant advance near the Turkish border in two years, Syrian opposition groups and Daesh media said.

More than 160,000 civilians are trapped in the fighting, which also forced the evacuation of one of the few remaining hospitals in the area, run by the international medical organisation Doctors Without Borders.

On Saturday, Daesh fighters staged two suicide bombings targeting “opposition forces” near Marea, Daesh said via its news agency, Aamaq.

Following the suicide bombings, Daesh militants entered Marea and fighting began inside the town, according to the Syrian Observatory for Human Rights, a Britain-based opposition media outfit that tracks Syria’s civil war.

The territorial gains around the rebel strongholds of Marea and Azaz, north of Aleppo city, are a blow to the Turkey and Saudi-backed rebels, who have been struggling to retain a foothold in the region while being squeezed by opponents from all sides. They also demonstrated the Daesh group’s ability to stage major offensives and capture new areas, despite a string of recent losses in Syria and Iraq.

The Daesh offensive targeting Syrian opposition strongholds near the Turkish border began Thursday night.

On Friday, militants of the group captured six villages near Azaz, triggering intense fighting that trapped tens of thousands of civilians unable to flee to safety while Turkey’s border remains closed. A few hundred fled west to the Kurdish-held enclave of Afrin.

People are “terrified for their lives,” the International Rescue Committee said in a statement. The group said it has received confirmed reports that at least four entire families, including women and children, were killed Friday on the outskirts of the town of Azaz.

The IRC runs centres for both children and women in Azaz and provides clean water and sanitation to a camp supporting 8,500 people. More than half the camp’s population has left to find safety elsewhere in the town, it said. The IRC also relocated its staff from the centres and camp to shelter to safer areas of Azaz until the situation enables them to return.

The UN refugee agency said it was “deeply concerned” about the fighting affecting thousands of vulnerable civilians.

“Fleeing civilians are being caught in crossfire and are facing challenges to access medical services, food, water and safety,” it said in a statement Saturday.

The advances brought the militants to within few kilometres of the rebel-held town of Azaz and cut off supplies to Marea further south. Marea has long been considered a bastion of moderate Syrian revolutionary forces fighting to topple President Bashar Al Assad.

Azaz, which hosts tens of thousands of internally displaced people, lies north of Aleppo city, which has been divided between a rebel-held east and government-held west.

A route known as the Azaz corridor links rebel-held eastern Aleppo with Turkey. That has been a lifeline for the rebels since 2012, but a government offensive backed by Russian air power and regional militias earlier this year dislodged rebels from parts of Azaz and severed their corridor between the Turkish border and Aleppo.

The predominantly Kurdish Syrian Democratic Forces (SDF), who are fighting for their autonomy in the multilayered conflict, also gained ground against the rebels.

In recent months, Syrian rebel factions in Azaz — which include mainstream opposition fighters known as the Free Syrian Army along with some ultraconservative Islamic insurgent factions — have been squeezed between IS to the east and predominantly Kurdish forces to the west and south, while Turkey restricts the flow of goods and people through the border.