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A protester, right, holds rocks in the air, ready to throw at riot police, as he urges other protesters on, while another protester, left, shows a bruise to a television crew, during clashes in Cairo, Egypt, in the early hours of Wednesday, Jan. 26, 2011. Image Credit: AP

Cairo: Police fired teargas and water cannon to disperse Egyptian protesters in Cairo in the early hours of Wednesday after a long day of unprecedented protests calling for President Hosni Mubarak to end his 30 year rule.

On Tuesday, two protesters and one policeman were killed in clashes and protests that erupted in several Egyptian cities, where demonstrators angry at poverty and repression have been inspired by this month's downfall of the leader of Tunisia.

"Down, Down Hosni Mubarak," protesters chanted after fleeing from the central Tahrir square. Some threw stones at the police, who charged them with batons to prevent the protesters returning to the square after it was cleared by using teargas.

"Bullies," fleeing protesters shouted. Others cried: "You are not men". Police sprayed a water cannon on protesters and moved in rows into the square.

Sporadic clashes took place into early Wednesday, but by the pre-dawn hours protesters appeared to have been dispersed. Police were milling about in Tahrir square, while street sweepers cleared away rocks and litter.

"Down with Mubarak" was still scrawled on a wall. Police trucks were lined up along a side street.

Some protesters had said they would try to regroup during the day on Wednesday. Security forces said protesters would not be permitted to reassemble.

Washington, a close ally and major donor, called for calm.

"The United States supports the fundamental right of expression and assembly for all people. All parties should exercise restraint and we call on the Egyptian authorities to handle these protests peacefully," State Department spokesman P.J. Crowley said in a statement.