Washington: Donald Trump on Monday demanded that Hillary Clinton shut down the charitable foundation founded by her husband, former US president Bill Clinton, branding it a “corrupt enterprise.”

The Republican presidential candidate also called for a special prosecutor to investigate his Democratic rival, accusing the FBI and Justice Department of a “whitewash” during their probe of her use of a private email server while secretary of state.

“The amounts involved, the favours done and the significant number of times it was done require an expedited investigation by a special prosecutor immediately, immediately, immediately,” Trump told a rally in Akron, Ohio, speaking of the State Department under Clinton.

The crowd responded with rowdy chants of “Lock her up! Lock her up!”

In an earlier statement, Trump called the Clinton Foundation “the most corrupt enterprise in political history.”

The charity has raised some $2 billion since it was founded in 2001 after Bill Clinton left office.

“It must be shut down immediately,” Trump said.

The Republican nominee said the foundation had received financial contributions from various countries “that discriminated against women and gays and everybody else.”

That remark apparently referred to various nations seen as having checkered histories on human rights that made generous donations to the foundation when Clinton, now the Democratic presidential nominee, served as President Barack Obama’s secretary of state between 2009 and 2013.

“I mean, that money — it should be given back. They should not take that money,” Trump told Fox.

James Carville, Bill Clinton’s top strategist in his ultimately successful campaign for the presidency in the 1990s, warned of dire consequences should Trump and his supporters manage to shutter the foundation.

“There will be people that are gonna die because of this,” Carville told CNN, estimating that the foundation helped around 10 million people get access to low-cost HIV drugs.

“All of the people that helped shut it down will say, ‘Gee, some people, a million people, had to die, but we had to prove a point,’” Carville said.

The Clinton Foundation disburses funds domestically and overseas, handing out some $218 million in 2014.

A firewall was supposed to have been in place to ensure that the foundation’s work remained completely separate from Hillary Clinton’s role as head of US diplomacy, but critics said that barrier was permeable at best.