Atlanta: Republicans in Washington seemed near panic Thursday in the light of a news report in which four women said Roy S. Moore, the Republican nominee for a US Senate seat in Alabama and an evangelical Christian, had made sexual or romantic overtures to them when they were teenagers and he was in his 30s.

Republican Senator Mitch McConnell, the Senate majority leader, said Moore should step aside before the December 12 special election if the allegations were true. But in Alabama, the fallout was uncertain for a candidate who is considered a hero in some circles for his conservative cultural stances.

Moore, a former chief justice of the Alabama Supreme Court, was twice removed from that office for his positions on same-sex marriage and a Ten Commandments display. On Thursday, he denied the allegations the women made about him in on-the-record interviews included in the report, published by The Washington Post.

And it was clear that many in his conservative base were in no mood to desert him in a race for a Senate seat Republicans consider crucial to maintaining their majority in the upper chamber.

John Skipper, 66, a former chairman of the Mobile County Republican Party, declared the allegations “total contrived media garbage.” Skipper said that he would still support the candidate and that he figured most of the Alabama Republicans he knew would probably do the same.

“Most of them will not be shocked,” he said, “and will rather be expecting these shenanigans being pulled by the Democrats as standard operating procedure.”

Whether Skipper’s prediction proves true remains to be seen. But the report unquestionably introduced new waves of uncertainty and turmoil into a race for the Senate seat vacated by Jeff Sessions, the attorney general.

The women cited in The Washington Post article said Moore had pursued them in the 1970s and 1980s when he was a lawyer in his early 30s.

Moore was defiant, denying the charges and attacking the news media.

“These allegations are completely false and are a desperate political attack by the National Democrat Party and The Washington Post on this campaign,” he said in a statement. He later attributed the news to “The Obama-Clinton Machine’s liberal media lapdogs.”

Brett Doster, an adviser to Moore, said the candidate would “absolutely not” drop out of the race, calling the charges “a fabricated November surprise.”

Others in Alabama shrugged at the allegations.

“There’s nothing to see here,” said Jim Zeigler, the state auditor and a longtime supporter of Moore. “Single man, early 30s, never been married, dating teenage girls. Never been married and he liked younger girls. According to The Washington Post account he never had sexual intercourse with any of them.”

But Moore’s candidacy appears to be in grave danger. Senate Republicans moved en masse to distance themselves from their nominee almost as soon as the news article was posted.

A statement from Vice President Mike Pence said: “The Vice President found the allegations in the story disturbing and believes, if true, this would disqualify anyone from serving in office.”

That statement was repeated by numerous Republicans, including the president who was travelling in Asia.

“Like most Americans the president believes we cannot allow a mere allegation, in this case one from many years ago, to destroy a person’s life,” Sarah Huckabee Sanders, the White House press secretary, said in statement from Danang, Vietnam, where the president is attending an economic summit meeting. “However, the president also believes that if these allegations are true, Judge Moore will do the right thing and step aside.”

“If these allegations are true, his candidacy is not sustainable,” said Sen. John Cornyn of Texas, the second-ranking Republican. Cornyn said he wanted to know more before withdrawing his endorsement of Moore.

The party, already reeling from the election losses they suffered Tuesday, is defending a two-seat majority in the Senate and faces a handful of difficult elections next year.

Moore’s candidacy had already worried party leaders who had embraced Moore despite his long record of incendiary comments about gays, Muslims and African-Americans.

Alabama election law indicates, with little ambiguity, that the deadline has passed for candidates to be replaced on the ballot. The state election code says a candidate who wishes to withdraw from a race must do so 76 days before Election Day. The Alabama vote is in little more than a month.

“It’s too late to substitute a candidate,” said John Merrill, the Alabama secretary of state, a Republican. “Judge Moore will be the candidate on the ballot with this election cycle remaining on the schedule it’s currently on.”

Republican lawyers and strategists in Washington were engaged in a furious search Thursday for creative ways around that restriction, seeking a loophole that would allow the party’s leadership in the state to anoint a new candidate. The prospect of a write-in candidacy, for a third candidate, was also under consideration, according to party aides.

Republican Senator Lisa Murkowski, who ran her own successful write-in campaign in 2010, said: “If in fact what I just read is true, he needs to get out of this race immediately. I think it’s pretty clear cut.”

She called for Senator Luther Strange, who was appointed to fill Sessions’ seat but lost to Moore in a bitterly contested Republican runoff in September, to run as a write-in.

One of the women, Leigh Corfman, told The Washington Post that she was 14 when Moore, 32 at the time, drove her to his home in Gadsden. He took off her shirt and touched her bra and underwear while also guiding her hand over his trousers, Corfman told The Post.

“I wanted it over with — I wanted out,” she told the newspaper.

CNN reported that it had spoken with Corfman’s stepfather, who said the family “stands by” what was reported in The Post.

Republican leaders are in a politically perilous situation, saddled with an embattled nominee unwilling to step aside in one of the country’s most conservative states. The charges reignited hostilities between McConnell’s political allies, who poured millions of dollars into the campaign to stop Moore, and President Donald Trump’s former chief strategist Stephen Bannon, who rallied support for the former justice.