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Andy Murray of Britain reacts after losing a point against Kevin Anderson of South Africa Image Credit: REUTERS

New York: Andy Murray crashed out of the US Open in the fourth round Monday, making his earliest Grand Slam exit since 2010 to end his run of 18 consecutive major quarter-finals.

South African 15th seed Kevin Anderson stunned the British third seed 7-6 (7/5), 6-3, 6-7 (2/7), 7-6 (7/0) to reach his first Grand Slam quarter-final.

Not since a third-round exit in the 2010 US Open had Murray been eliminated so early at a Grand Slam tournament.

Anderson, 1-5 in prior matches against Murray, ended an 0-15 career hoodoo against top-10 opponents and an 0-7 hex in fourth-round Slam matches to book a last-eight date with Swiss fifth seed Stan Wawrinka, the reigning French Open champion.

“I’m just so excited to be through,” said Anderson. “Beating a guy like Andy, I really feel like I’ve taken a step forward. It’s amazing. I feel like it’s a great accomplishment.”

Wawrinka defeated US left-hander Donald Young 6-4, 1-6, 6-3, 6-4.

He dropped his first set of the tournament but reached an eighth quarter-final in his past nine Grand Slams, denying 68th-ranked Young his first Slam quarter-final.

Anderson is the first South African in New York’s last 16 since Wayne Ferreira in 2002.

He came in off a third career title at Winston-Salem.

With New York City FC and former England midfielder Frank Lampard watching from the player’s box, Murray fell behind two sets and a break, roared back, but ultimately could not win the tension-packed encounter.

Big-serving Anderson ripped a forehand winner on the final point of the opening tie-break to take the set after 69 minutes, then broke Murray’s first service game of the second set on the way to a 5-1 edge.

Murray broke back and held and had a break chance in the ninth game, but Anderson saved it and finally took the set on his fifth chance, ripping his 12th ace of the match up the middle.

Murray, whose first forehand winner only came in the last game of the second set, sat down and uttered a profanity-laced tirade to himself picked up by courtside microphones, the Briton unhappy at Anderson walking off for a toilet break and asking the umpire about the definition of reasonable time for the pause.

“I’ve been waiting for three minutes at the line,” Murray complained, anxious to serve to open the third set.

Murray promptly surrendered a break, Anderson hitting a cross-court winner on his third break chance, sending Murray to his chair ranting about the break length.

“You get these grey areas all the time,” Murray said between sips from his water bottle. “They just exploit them and you do nothing.”

Down two sets and a break, Murray answered the call, breaking Anderson’s next two service games before surrendering a break and holding to the tie-break, in which he jumped ahead 5-1 and later ended the 70-minute set with his 12th ace.

Murray denied Anderson on two break points in the fourth game of the fourth set and they held to a tie-break that Anderson dominated from the start.

Young, the first player since Gilles Muller in 2008 to rally twice from two sets down in a US Open, 0-17 in such situations before this week, but he fell to 3-18 against top-10 opponents.

Wawrinka, 30, was upset by Young in a fifth-set tie-breaker at the 2011 US Open, but took the first set on a backhand return winner in the third game.

Young, 26, won the second set as the Swiss netted forehands to surrender breaks in the fourth and sixth games of the second set, Wawrinka smashing his racquet to the cement at one stage in frustration.

“Sometimes you don’t control yourself. You need to put the pressure out,” Wawrinka said. “I played really well after.”

“The set was so quick. I wasn’t there mentally. Calmed down a little bit. I began to be more aggressive, started moving my feet better.”

Wawrinka raced ahead 5-0 in the third set and hung on to finally take the set on a running backhand winner, then opened the fourth set with a break and held to the end.