Paris: Andy Murray wasted a match point before being knocked out 5-7 7-6 6-2 by Polish qualifier Jerzy Janowicz in the third round of the Paris Masters on Thursday.
Scot Murray lost focus as he served for the match in the second set and was then battered by the hard hitting Janowicz, who ended the contest with a forehand winner and collapsed in joy.
World number three Murray's defeat means that for the first time since the 2010 Paris Masters was won by Swede Robin Soderling, a Masters title will be claimed by player outside of the Big Four.
As another energy-sapping season draws to and end, world number four Rafa Nadal and Roger Federer opted not to play in the French capital while Serb Novak Djokovic was dumped out of the tournament by American Sam Querrey in the second round on Wednesday.
Janowicz face either the eighth-seeded Serb Janko Tipsarevic, who is looking to secure a World Tour Finals spot, or Argentine Juan Monaco, the ninth seed.
The 21-year-old Pole, who stands at 2.03 metres had not faced a break point in his first two Paris matches.
But that run was unlikely to stay intact against a grand slam champion and he fell 15-40 behind in the 11th game.
He saw off the first break point by following a big first serve at the net, only to double fault on the second.
Murray, who mixed his game with drop shots to break Janowicz's rhythm, claimed the set when his opponent sent a forehand long.
The Pole, who was playing in a challenger tournament in Mons, Belgium, last month, refused to give up but in the seventh game of the second set, a sizzling Murray return gave the Scot a break.
Murray lost focus when serving for the match, however, netting a routine forehand on match point, and dropped serve when he sent a backhand wide as the set went into a tiebreak.
Janowicz levelled the contest with a jaw-dropping drop shot on set point, and quickly opened a 4-1 lead as Murray, who had showed signs of nerves in the second set, failed to regain his composure.
Earlier, Czech Tomas Berdych, the fifth seed, recovered from a terrible start to down South African Kevin Anderson 1-6 6-3 6-4.
He will next face Frenchman Gilles Simon, who advanced without hitting a ball after Japanese 15th seed Kei Nishikori withdrew because of an ankle injury.