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FILE - In this Dec. 3, 2015 file photo, Seth MacFarlane attends Sinatra: Voice for a Century concert in New York. MacFarlane is going to star in and produce a sci-fi TV series set 300 years in the future. Fox said Wednesday, May 4, the series, described as a comedic drama, is intended for the network's 2017-18 season. (Photo by Greg Allen/Invision/AP, File) Image Credit: Greg Allen/Invision/AP

Fox is staying in the Seth MacFarlane business.

The network announced Wednesday that it has ordered 13 episodes of a new comedic drama created and executive produced by the Emmy-winning mind behind Family Guy and Ted.

But in a noteworthy twist, MacFarlane will also star in the as yet untitled, hourlong, live-action series, which is set 300 years in the future aboard the Orville, “a not-so-top-of-the-line exploratory ship in Earth’s interstellar Fleet.”

“Seth has one of the most original voices — in every sense of the word — and we’ve been waiting for him to bring us a project as special as this one,” said Fox Television chief executives Dana Walden and Gary Newman in a statement, describing the series as “classic Seth — fresh and funny, incredibly smart, wickedly subversive.”

The network’s long-standing partnership with MacFarlane dates back to the premiere of Family Guy in 1999. The animated series is in its 13th season and has been renewed through the 2016-17 season.

MacFarlane has also been involved as a co-creator or executive producer on the animated series American Dad!, The Cleveland Show and Bordertown, and on the documentary Cosmos: A Spacetime Odyssey, all for Fox.

The network currently plans to air the new series in the 2017-18 season.