Los Angeles: Angelina Jolie has filed for divorce from Brad Pitt and is seeking custody of their six children, TMZ reported Tuesday, spelling the end for "Brangelina," one of Hollywood's highest-profile celebrity couples.
According to the entertainment news site, the 41-year-old Jolie filed legal documents on Monday citing irreconcilable differences with Pitt, 52, listing their date of separation as September 15.
Two of the world's biggest stars, they formed a Hollywood power couple second to none, so famous they were known simply by their combined first names.
The A-listers wed in France in August two years ago, but have been together since 2004 and have six children together, three of whom are adopted.
Jolie is seeking physical custody of the children, with visiting rights for Pitt, according to TMZ, which said she was not seeking spousal support.
Pitt came into the public eye 25 years ago with a much-talked-about shirtless debut as eye-candy in the hit movie Thelma and Louise - and went on to become a household name in Hollywood.
A three-time Oscar nominee for his acting, Pitt took home a golden statuette for best picture in 2014 as a producer of 12 Years A Slave.
He has built a resume of varied film roles, starring alongside some of the industry's other mega-watt stars: with Tom Cruise in Interview with a Vampire, Anthony Hopkins in Legends of the Fall and George Clooney in Ocean's Eleven.
Jolie catapulted to stardom with her role in 1999's Girl, Interrupted, taking home an Academy Award for best supporting actress for her fierce portrayal of a rebellious woman in a mental institution.
She has since played everything from a fairy tale villain (Maleficent) to a sexy video game heroine (Lara Croft: Tomb Raider) to the widow of assassinated American journalist Daniel Pearl (A Mighty Heart).
The red carpet darling is now better known for her humanitarian work than for her tabloid-ready actions, having served for several years as a goodwill ambassador for the United Nations High Commissioner for Refugees.
In 2012, she was promoted to special envoy and has visited refugees around the world, from Syria to the Democratic Republic of Congo and Rwanda.
More recently, she has been a vocal advocate for victims of sexual violence in war zones, co-hosting a global summit on conflict rape in 2014 in London.
She also was made an honorary dame by Queen Elizabeth II.
She is one of the world's most visible symbols in the battle against cancer, having undergone a double mastectomy and removal of her ovaries and fallopian tubes to prevent an aggressive form of the disease that killed her mother, grandmother and aunt.
The actress had been married twice before, to actors Jonny Lee Miller and Billy Bob Thornton.
Pitt, born to a middle-class family in Oklahoma, supported himself in early adulthood with a series of part-time jobs, including as a chauffeur, removal man and even dressing up in a chicken suit to advertise a fast-food chain.
But from 1987 the work started to trickle in, with bit parts in the television series Dallas and 21 Jump Street and a few low-budget movies.
His position as a Hollywood golden boy was assured by his 2000 marriage to Friends star Jennifer Aniston, which made them one of the hottest couples in the world.
Pitt and Jolie fell in love on the set of action film Mr & Mrs Smith, although they didn't get engaged until 2012.
In May 2006 Jolie gave birth to their first child, a girl named Shiloh.
Their joint fortune is estimated at over $300 million, and they are among the highest paid stars in Hollywood.
Jolie, the daughter of Oscar winner Jon Voight, made her directorial debut in 2011 with In the Land of Blood and Honey, an unflinching drama about rape as a weapon in wartime Bosnia.
Her fourth feature behind the camera, historical thriller First They Killed My Father, is being released on Netflix later in the year.