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Rosie O'Donnell accepting the Isabelle Stevenson Award on stage at the 68th annual Tony Awards at Radio City Music Hall in New York. Image Credit: AP

Rosie O’Donnell is leaving The View for a second time.

Her publicist, Cindi Berger, said on Friday that the outspoken co-host of the ABC daytime chat show is exiting next week to focus on her five children after the breakup of her marriage.

Berger says O’Donnell and Michelle Rounds, her wife of three years, split in November.

The 52-year-old O’Donnell had returned to The View only last summer. Her initial yearlong stay ended stormily in 2007.

Now in its 18th season, the programme recently was the target of rumours that a fellow panellist, Rosie Perez, had left for good to appear in a new Broadway play. But she returned this week.

Moderator Whoopi Goldberg and Nicolle Wallace remain with Perez on the show, which was created by Barbara Walters in 1997.