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Oprah Winfrey has racked up memorable moments during her long television reign. Some were moving, some embarrassing — to her or others — and a handful became pop-culture landmarks. Here are highlights through the years:

Winfrey gets the final TV interview with pianist-showman Liberace, six weeks before his Aids-related death, 1986.

Wearing slim-fitting, size 10 Calvin Klein jeans, Winfrey wheels a wagon loaded with fat onto the show's set to represent her 30-kilos weight loss, 1988. She later called the show her "biggest, fattest" mistake.

Michael Jackson gives his first TV interview in more than a decade and discusses his oddly changing looks on a highly rated live prime-time special, 1993.

Oprah's Book Club is introduced, giving a single-handed jolt to the publishing industry and vaulting her choices to the best-seller list and instant fame, 1996.

On the sitcom Ellen, star Ellen DeGeneres' character confides that she's lesbian to a therapist played by Winfrey, while DeGeneres herself came out as gay, 1997.

Winfrey bestows a car on the nearly 300 people in her studio audience in the 19th season premiere, a $7 million (Dh25.7 million) giveaway, and famously exclaims, "You get a car! You get a car! You get a car! Everybody gets a car!", 2004.

Tom Cruise offers a madcap couch-jumping demonstration of affection for Katie Holmes, 2005.

Winfrey chews out author James Frey on her show in 2005.

Barack Obama's presidential campaign gets the Winfrey seal of approval in 2008.

A grilled-chicken promotion on Oprah.com sends feathers flying at the KFC fast-food chain, with some outlets running out of the meals for freebie-hungry throngs, 2009.

Winfrey takes a stand against domestic violence following Chris Brown's assault on then-girlfriend Rihanna in 2009.

Sarah Palin's first interview about her new book, Going Rogue: An American Life, and the meeting, which opens with Winfrey asking Palin if she felt snubbed at not being invited during the campaign, is cordial, 2009.